Postdoc Positions at Duke
Below are some of the postdoctoral positions available at Duke University. Please note that this list is NOT comprehensive. If you do not see a position in your area of interest, you should directly contact Duke faculty who are working in your research area(s) to inquire about possible positions.
Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, national origin, race, religion, sexual orientation, or veteran status.
|Position Title||Department||Job Description||Deadline to apply|
|Postdoctoral Associate, In Vitro Modeling of Human Skeletal Muscle Disease||Biomedical Engineering||
A postdoctoral position is immediately available in the area of human skeletal muscle biology and tissue engineering. The goal of the project is the development of 3-D cell culture models of functional human skeletal muscle tissue using primary myogenic cells from human muscle biopsies as well as satellite cells derived from human induced pluripotent stem cells (hiPSCs). Myogenic cells will be derived from patients with diverse pathologies including the glycogen storage disease type II (Pompe disease) and different types of muscle dystrophies. Resulting engineered muscle tissues will be optimized for functionality, validated for a pathophysiological phenotype, and utilized in molecular, pharmacological, and gene therapy studies. Functional measures will include non-invasive monitoring of generated contractile force and intracellular calcium transients. Studies in rodents will be further employed to explore the utility of the human engineered muscle for predictive screening of novel therapeutics.
|Sunday, February 15, 2015|
|Postdoctoral Associate - Animal Surgery; Regenerative Medicine for Cardiac and Skeletal Muscle Disease||Biomedical Engineering||
We are seeking a highly qualified individual with extensive experience in animal surgery and handling. The main research area of our group is regenerative therapies for cardiac and skeletal muscle injury and disease. Experiments will involve induction of myocardial infarction and transverse aortic constriction in mouse, rat, and mini-pig hearts, surgical implantation of a cardiac tissue patch onto rat and mini-pig hearts, and follow-up physiological and hemodynamic studies in live animals and explanted hearts. Furthermore, surgical experience in inducing muscle hindlimb ischemia and generation of large volumetric muscle loss in mice and rats and implantation of engineered muscle tissues at the site of muscle injury are highly desired.
|Saturday, January 31, 2015|
|Postdoctoral Associate - Physiology and Pharmacology of Human Skeletal Muscle Microtissues||Biomedical Engineering||
A postdoctoral position is immediately available in the area of human skeletal muscle tissue engineering and metabolism. We have recently generated human skeletal muscle microtissues that recapitulate key structural and functional aspects of native skeletal muscle including an aligned myofiber architecture with robust cross-striations and the ability to generate spontaneous, electrically stimulated, and chemically stimulated contractions and calcium transients. The goal of the project will be to utilize these microtissues for modeling of human muscle disease, pharmacological, metabolic, and physiological studies. Specifically, electrical stimulation will be applied to simulate different regimes of muscle exercise and resulting changes in muscle fiber type, responsiveness to insulin challenge, calcium handling, contractile, metabolic, and biochemical responses will be studied. The overall goal will be to establish utility of the human engineered muscle tissues as a pre-clinical assay for development of new drug and gene therapies.
|Wednesday, December 31, 2014|
|Postdoctoral Associate, Medicine/Cardiology||Duke Medicine/Cardiology||
A postdoctoral position is available to delineate the relationship between beta-arrestin ubiquitination and inflammatory signaling. This is an entry-level postdoctoral position but one year of previous post-doctoral experience is acceptable. We aim to understand the molecular mechanisms that connect ubiquitination, trafficking and signal transduction. We employ a wide range of techniques ranging from in vitro assays to animal models.
|Friday, January 30, 2015|
|Postdoctoral Associate, Molecular Genomics||Duke University Medical Center||
Position: Characterization of the epigenetic mechanisms associated with insulin production in ageing pancreatic islets. Duke University School of Medicine has a two year industry sponsored Postdoctoral Fellow position to conduct research to elucidate the epigenetic mechanisms that contribute to the ‘islet brake’ hypothesis associated with the change in proliferative capacity of young to old islets. It is predicted that these DNA methylation differences result in changes to mRNA expression between islet ages in genes important to cellular transition and function. The position involves the generation of next generation sequencing data from young and old rat pancreatic islets to profile DNA methylome and transcriptome to identify the signatures of islet aging, and ChIP-Seq data from two transcription factors known to regulate islet proliferation. The Postdoctoral Fellow will be responsible for establishing experimental approaches and design in conjunction with PI (Simon Gregory, PhD), be able to analyze and interpret data produced, and to synthesize these findings into manuscripts for publication and/or formatted for the submission of grants. The postdoctoral fellow will be responsible for developing and conducting molecular analyses of DNA methylation and RNA profiling as part of a large group focused on the molecular characterization of pancreatic islet function in diabetes. The Postdoctoral Fellow will be expected to participate in Dr. Gregory’s ongoing lab meetings and the larger research group. The Postdoctoral Fellow will be housed at the new Duke Molecular Physiology Institute under the supervision of Dr. Gregory.
|Friday, January 9, 2015|
|Postdoctoral Associate, Duke Cancer Institute||Duke Cancer Institute||
An NIH grant funded postdoc position is available in the Kirsch lab at Duke to use next-generation mouse models of cancer to dissect the role of the tumor microenvironment in cancer progression and response to therapy. Our lab has generated novel genetically engineered mice to enable dual recombinase technology in which Flp recombinase initiates cancer so that Cre recombinase mutates other genes specifically in stromal cells. For example, we recently applied dual recombinase technology to study the role of endothelial cells in mediating tumor development and response to radiation therapy in primary sarcomas (Moding et al, Journal of Clinical Investigation 2014).
|Friday, January 30, 2015|
|Postdoctoral Associate, Center for In Vivo Microscopy, Duke Radiology||Center for In Vivo Microscopy, Duke Radiology||
A post-doctoral position is available at the Duke University Center for In Vivo Microscopy (www.civm.duhs.duke.edu)to work with magnetic resonance microscopy imaging equipment and applications. The Center for In Vivo Microscopy (CIVM) is an NIH/NIBIB Biomedical Technology Resource Center dedicated to the development of preclinical imaging methods and application of these methods to important biomedical questions. The CIVM has a strong history in high-field magnetic resonance microscopy, with 7 MR imaging systems ranging from 1.0 to 9.4 T, along with microCT, microSPECT, confocal, and Near IR systems. We have a robust computational environment with a high-performance cluster and GRID server.
|Thursday, January 1, 2015|
|Postdoctoral Associates, Genetic Association Studies of Human Aging, Health and Lifespan||Biodemography of Aging Research Unit||
Two new postdoctoral research opportunities are available in the newly organized Biodemography of Aging Research Unit at the Center for Population Health and Aging, Duke University, Durham, NC, USA. Duke is a world class educational and research institution. It is consistently listed among top 10 universities in the USA and around the globe. We are looking for open-minded postdoctoral investigators who can apply cross-disciplinary approaches to resolving challenging research questions in areas of genetics of human aging, complex diseases, and longevity. The research agenda will involve analyses of genetic associations with aging/health/longevity phenotypes using large sets of human genetic and phenotypic longitudinal data, including Framingham Study, CHS, MESA, ARIC, HRS, and LOADFS. Research will also be performed using advanced functional genomics tools for the interpretation of results and for obtaining new insights into the roles of genetic factors in aging, age-associated health decline,and longevity. Our interdisciplinary research team includes outstanding scientists with diverse backgrounds in genetics, epidemiology, statistical modeling, medical biology, demography, and other fields, who pursue cutting edge research on aging. A broad objective is a better understanding of mechanisms connecting physical aging, age-associated health decline and lifespan, and genetic and phenotypic heterogeneity of aging and longevity - through association studies, advanced biological concepts, bio-statistical modeling, functional genomics approaches, and in-depth biological interpretation of results. Our team has published more than 120 peer-reviewed papers on related topics during last decade (see http://www.ncbi.nlm.nih.gov/pubmed/?term=yashin+a%5Bauthor%5D).
|Sunday, November 30, 2014|
|Duke Law & Biosciences Postdoctoral Fellowship Program||Duke Science & Society||
Duke University Science & Society invites applications for the 2015-2016 Law & Biosciences Postdoctoral Fellowship Program. This fellowship is intended for individuals with a doctoral degree (JD, PhD, MD, DPhil) who are interested in an academic or policy career working on issues in science and society, with a particular interest in the legal, ethical, and social implications of the biosciences. Science & Society: Duke Science & Society is an interdisciplinary initiative that examines the wide-ranging and integral role of science in social institutions and culture. Science & Society integrates and fosters innovation in related research, education, and engagement at Duke by adopting a pluralistic approach to understanding how science and human endeavors intersect with a specific focus on ethical, legal, and social implications for science. For more information, visit our website at http://www.scienceandsociety.duke.edu.The Fellowship: The Law & Biosciences Fellowship is a residential fellowship that provides an opportunity to become involved in the activities of Science & Society and Duke University, while pursuing independent scholarship at the intersection of science and society. Candidates are offered a one-year position, with a possibility of renewal for a second one-year position. Fellows dedicate approximately one third of their time to supporting the activities of Science & Society, one third of their time supporting the research of the Director of Science & Society, and one third of their time on independent research. Fellows are provided with office space, a competitive stipend, and benefits. Fellowship Responsibilities:Independent scholarship at the intersection of biosciences and law:- Complete at least one mentored research project which culminates in a manuscript of publishable quality- Participate in bioethics conferences, workshops, and seminars as appropriateSupport Research of Director of Science & Society:- Provide research support on research projects, presentations, and grant proposals under the supervision of the Director of Science & Society- Draft manuscripts, engage in empirical and qualitative research activities in support of the research projects of the Director of Science & SocietySupport Science & Society activities:- Organize and implement for the master’s program the colloquium series “Contemporary Issues in Bioethics & Science Policy,” which involves coordinating a series of speakers for the course- Help plan and implement Science & Society workshops and events, including the Distinguished Lecture Series and the Science & Society Roundtable- Implement a training program for young researchers interested in learning more about Science & Society topics- Support the work of Science & Society, including research, education, and engagement- Complete other tasks as requested
|Sunday, February 1, 2015|
|Postdoctoral Associate, Skeletal Development, Disease, and Repair Mechanisms||Department of Orthopaedic Surgery||
A postdoctoral research position is available in the Hilton Laboratory within the Duke Orthopaedic Cellular, Developmental, and Genome Laboratories at Duke University School of Medicine. The primary research focus of this position will utilize novel mouse genetic and surgical models to study skeletal development, disease, and repair/regeneration with a particular emphasis on identifying underlying molecular mechanisms that contribute to normal skeletal development and repair processes or the pathogenesis of disease. One of the major focuses of the Hilton Lab is to utilize conditional (Cre/LoxP) mutant and transgenic mouse models coupled with primary cell culture and biochemistry to understand the contributions of various signaling pathways to the development and maintenance of the growth plate and joint cartilages, as well as, to skeletal fracture repair and bone regeneration.
|Friday, December 19, 2014|