Postdoc Positions at Duke
Below are some of the postdoctoral positions available at Duke University. Please note that this list is NOT comprehensive. If you do not see a position in your area of interest, you should directly contact Duke faculty who are working in your research area(s) to inquire about possible positions.
Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, national origin, race, religion, sexual orientation, or veteran status.
|Position Title||Department||Job Description||Deadline to apply|
|Postdoctoral Associate, Duke Molecular Genetics and Microbiology||Molecular Genetics and Microbiology/Neurobiology||
Postdoctoral position is available in the laboratory of Dong Yan (https://mgm.duke.edu/faculty-and-research/primary-faculty/dong-yan-phd). Our laboratory focuses on dissecting molecular mechanisms of neural circuit formation, regulation and degeneration in C. elegans. We apply classic genetic manipulation combined with live imaging and biochemical approaches to uncover key insights into neural circuit formation in young animals and neural degeneration in old animals. We currently have projects focusing on the following areas: i) RME circuit formation; ii) gap junction dynamics; iii) aging related neurodegeneration .
|Wednesday, September 30, 2015|
|Postdoctoral Associate, Immunology||Immunology, Duke University Medical Center||
The Ciofani lab studies the transcriptional regulatory networks that govern inflammatory immune cell development and function. We are seeking motivated, talented candidates for full-time postdoctoral positions to be held in the Department of Immunology, Duke University Medical Center. Positions are immediately available in two exciting project areas: (1) A National Multiple Sclerosis Society-funded position aimed at identifying novel genetic mediators of multiple sclerosis (MS). The project applies an integrative network approach, combining regulatory information from global transcriptomic and chromatin conformation measurements of human CD4 T cells with genome wide association study data to identify and prioritize MS risk-linked genes. The researcher will apply established protocols as well as develop novel methodologies to achieve this goal. The study will involve high-throughput sequencing; CRISPR/Cas9 genome targeting; and screening of gene candidates in mouse models of MS, thus providing the successful fellow with experience in several cutting-edge techniques. The ideal candidate will have a strong background in immunology and/or molecular biology; and be interested in managing an interdisciplinary project focused on the generation and computational analysis of large data sets.(2) The gene regulatory mechanisms governing inflammatory T cell development, plasticity, and function. Our focus is on the role of AP-1 family transcription factors and non-coding RNAs. The researcher will take advantage of cell culture methods; global genomic regulatory assessments (RNA, accessibility, transcription factor occupancy); and in vivo models of infection and autoimmune disease in gene-deficient animals to perform functional and mechanistic studies.Appointments will be made on a renewable one-year contract with the expectation of at least a three-year commitment. Positions are available immediately and will be filled as soon as possible.
|Friday, July 31, 2015|
|Postdoctoral Associate, Genetic Association Studies of Human Health, Aging, and Lifespan||Duke Social Sciences Research Institute||
An exciting research opportunity is available at the Biodemography of Aging Research Unit, Social Sciences Research Institute, Duke University for a National Institute on Aging (NIA) funded project. Our research team is looking for an open-minded and talented post-doc who is excited about aging-related science. Candidate should be able to perform multiple tasks in a multi- and inter-disciplinary environment and to apply integrative approaches in studies of complex research questions in genetic susceptibility to human aging, age-related diseases and lifespan.The research agenda will include (but not limited to) working with large-scale datasets with phenotypic and genetic information, statistical analyses of these data, analytic work with the results, functional genomics analyses, mathematical modeling, and publishing scientific papers. Particular focus will be on the analyses of associations of SNPs with heath and aging/longevity related traits and on addressing the relationships among genetic regulators of physiological aging, senescence, health and lifespan, using several large longitudinal human datasets.
|Friday, September 25, 2015|
|Postdoctoral Associate, Biomedical Engineering||Biomedical Engineering, Pratt School, Duke University||
The Randles lab has an immediate opening for a Postdoctoral Associate to conduct applied research in the area of large-scale hemodynamic simulations. We are interested in questions that are of crucial importance for vascular disease reserach, and we use mathematical and computational techniques to approach them. In particular, we are coupling a kinetic representation of fluid mechanics with a deformable representation of suspended bodies and vessel walls to create patient-specific simulations of hemodynamics. Such methods are extremely computationally intense and requre use of large-scale supercomputers. The focus of the candidate will be on the development and application of multiscale/multiphysics software to study the localization and progression of disease. The position is available for immediate hire with a 2-year term and opportunity for additional annual renewal contingent on performance and funding availability.
|Tuesday, September 15, 2015|
|Research Scientist, Duke Viral Vector Core||Viral Vector Core, Duke Department of Neurobiology||
The Duke University School of Medicine Viral Vector Core (VVC) seeks to hire a Research Scientist to direct activities of the Core. The VVC is based in the Department of Neurobiology at the Duke University Medical Center and serves the Duke community in the design and preparation of custom viral vectors (e.g. adeno-associated virus, lentivirus, rabies virus) for laboratory research purposes. Responsibilities of the position include working with investigators to provide guidance on development of viral constructs that will meet their research needs, development and optimization of new viral vector methodologies, design and construction of custom viral vectors, preparation of viral stocks for core facility customers, supervision of VVC facility personnel, and oversight for financial management of the VVC. Further description of the VVC and its mission can be viewed at http://sites.duke.edu/dvvc/.
|Friday, July 31, 2015|
|Postdoctoral Associate, Duke Cancer Institute, Duke University Medical Center||Duke Cancer Institute, Duke University Medical Center||
A full time postdoctoral position is available in the Genitourinary (GU) Oncology Research Laboratory to study molecular mechanisms underlying tumor aggressiveness. The Laboratory focuses on preclinical studies, correlative science with archived clinical trial specimens and prospective specimen collections and analyses to further understand the biology underlying GU malignancies and to discover better treatment options for patients. The Laboratory is situated in an open laboratory setting with interactive and collaborating scientists at all academic levels. Some studies will be done in collaboration with the David H. Murdock Research Institute and Core Laboratory. The research involves RT-PCR, targeted sequencing and circulating nucleic acid and small molecule profiling from blood specimens from Caucasian American and African American men who have developed prostate cancer and those who have not developed prostate cancer. Researchers have access to all essential instrumentation for the study.
|Friday, August 28, 2015|
|Postdoctoral Associate, Duke Molecular Genetics and Microbiology||Department of Molecular Genetics and Microbiology, Duke SOM||
The Marchuk lab has an immediate opening for a Postdoctoral Associate to investigate the molecular pathology of Cerebral Cavernous Malformations. We have previously shown that CCM pathogenesis follows a two-hit mutation mechanism where the inherited, constitutional CCM gene mutation is augmented by a somatic mutation occurring in the remaining wild-type copy gene. We have further shown that this second hit occurs in the endothelial cells (ECs) of the lesion. But it is unknown whether this mutation is the sole or even main cause of the progressive shift of the CCM from a single dilated vessel to the mature, multi-cavernous, hemorrhagic lesion. We hypothesize that CCM-deficient ECs exert a dominant, non-cell autonomous effect on CCM pathogenesis, recruiting non-mutant cells into the developing lesion. We will test this hypothesis by crossing the multicolor Cre-reporter, R26R-Confetti, into a floxed Ccm mutant line to visually trace the lineage of the mutant ECs in the developing lesion. In parallel, working with the Phenotyping and Human Tissue Core, we will analyze the micro-dissected endothelial cells from human CCMs to determine the anatomic location of the somatically mutated cells in the different caverns of the lesion. These data will complement the murine lineage tracing studies to determine whether the original somatic mutation clonally expands into all regions of the growing CCM lesion. Finally, based on information gained from studies of signaling aberrations associated with loss of CCM proteins, we will determine the significance of other signaling pathways (Wnt/beta-catenin, ROS, NOTCH, KLF2, others) in CCM lesion pathogenesis. We will employ pharmacological inhibitors of these signaling pathways with our Ccm1 and Ccm3 mouse models, and working with the Core, determine the effects of inhibition of these pathways on lesion size, number, biomarkers of maturation, and the clinically important phenotype of hemorrhage. These combined analyses will identify the molecular and signaling aberrations that are critical for lesion maturation, providing new hypotheses for lesion pathogenesis, and identifying new targets for CCM therapy.
|Friday, July 24, 2015|
|Postdoctoral Associate, Ophthalmology||Duke Department of Ophthalmology||
A postdoctoral research position exploring the molecular and cellular pathogenesis of retinal diseases is available in the laboratory of Dr. Goldis Malek at the Albert Eye Research Institute at Duke University in Durham, NC. Research in our laboratory focuses on identifying signaling pathways mediated through nuclear receptors, including relevant molecular targets and their consequential impact on the progression and severity of age-related macular degeneration and diabetic retinopathy.
|Friday, July 10, 2015|
|Postdoctoral Associate, Genetic Association Studies of Human Health, Aging, and Lifespan||Duke Biodemography of Aging Research Unit (BARU)||
Available Immediately: An exciting research opportunity at the Biodemography of Aging Research Unit, Social Sciences Research Institute, Duke University for the National Institute on Aging (NIA) funded projects. Our research team is looking for an open-minded and talented post-doc who is excited about the science and can conduct multi-tasking work in multi- and inter-disciplinary environment to apply integrative approaches in studies of complex research questions in genetic susceptibility to human aging, age-related diseases and lifespan. The position assumes communication skills and collaborative and creative work in multi- and inter-disciplinary environment. The researcher will exploit existing (developed in our group and elsewhere) and develop new approaches to the analyses and interpretation of findings in genetic association studies of human aging, health, and lifespan aiming to significantly improve efficiency of genetic discoveries. The research agenda will include (but not limited to) working with large-scale datasets with phenotypic and genetic information, statistical analyses of these data, analytic work with the results, functional genomics analyses, mathematical modeling, and publishing scientific papers. Particular focus will be on the analyses of associations of SNPs with heath and aging/longevity related traits and on addressing the relationships among genetic regulators of physiological aging, senescence, health and lifespan, using several large longitudinal human datasets.
|Friday, August 7, 2015|
|Postdoctoral Associate, Division of Hematologic Malignancies and Cellular Therapy||Department of Medicine, Duke University Medical Center||
Seeking motivated candidates for postdoctoral positions at the Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center. The position is available immediately. The overall duties and responsibilities for this position are: 1) to develop hypothesis-driven approaches to improve hematopoietic stem cell transplantation using mouse animal model or to identify novel therapeutic targets for the treatment of multiple myeloma; 2) to perform experiments and collect data, and to evaluate experimental data and establish the relevance to experimental problems under investigation; 3) to prepare research results for publication in reports, papers, journals, books, and other media; and 4) to train and direct support personnel.
|Friday, July 31, 2015|